the bond between the a-carbon and the carboxyl carbon of that residue (known as psi ).the bond between the -carbon and the amino nitrogen of that residue (know as phi ).The two bonds within each amino acid residue freely rotate.The mutation results in: 1) arrays of aggregates of hemoglobin molecules, 2) deformation of the red blood cell, and 3) clotting in blood vessels and tissues.It is caused by a change of amino acids in the 6th position of globin (Glu to Val).A single amino acid substitution can give rise to a malfunctioning protein, as is the case with sickle-cell anemia.The primary structure of a protein determines the other levels of structure.The order in which the amino acids are covalently linked together.Quaternary structure describes the number and relative positions of the subunits in a multimeric protein Some proteins are made of multiple polypeptides crosslinked (connected) with each other.Tertiary structure: the three-dimensional structure and/or arrangement of all the amino acids residues of a polypeptide chain. ![]()
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